Acyclovir 500 mg iv
HOW supplied Acyclovir Injection acyclovir is supplied as acyclovir sterile vials, each acyclovir containing acyclovir sodium equivalent to acyclovir 500 acyclovir mg of acyclovir dosage acyclovir acyclovir for acyclovir intravenous acyclovir administration in acyclovir uses 20 mL of water for injection, tray of 10 (NDC ). The half-life and total body clearance of acyclovir are dependent on renal function as shown in Table. Other warnings and precautions The labels shall contain the acyclovir following statements:For intravenous infusion onlyKeep out of the acyclovir reach and sight of childrenStore below 25CPrepare immediately prior to useDiscard unused acyclovir solution.5 Interaction with other medicinal products and other forms of interaction. For herpes encephalitis) specific care regarding renal function should acyclovir be acyclovir taken, particularly when patients acyclovir are dehydrated or acyclovir have acyclovir any acyclovir renal constituted Zovirax.V. 4 This drug is available at acyclovir a higher level acyclovir co-pay. Pharma Services and Drug Enquiries, india is the acyclovir world's capital for quality medicines, be acyclovir it pharmaceutical formulations, herbal medicines or nutraceuticals. QL Quantity Limits Drugs that have acyclovir quantity limits associated with each prescription. Neurological effects including confusion, hallucinations, agitation, seizures and coma have been described in association with overdosage. Compare formulary status to other drugs in the same class. Route of administration: Slow intravenous infusion over 1 hour. Acyclovir was tested in 16 in vitro and in vivo genetic toxicity assays. Storage Conditions for Acyclovir (500 mg) Store it at acyclovir room temperature (15 acyclovir to 25C) and protect from moisture. Most commonly, these are "non-preferred" brand drugs or specialty prescription products. Pregnancy Teratogenic Effects Pregnancy Category B Acyclovir administered during organogenesis was not acyclovir teratogenic in the mouse (450 mg/kg/day, PO rabbit (50 mg/kg/day, SC and IV or rat (50 mg/kg/day, SC). In a rat peri- and post-natal study at 50 mg/kg/day, SC, there was a statistically significant decrease in group mean numbers of corpora lutea, total implantation sites, and live fetuses. Herpes Simplex Encephalitis Sixty-two patients acyclovir ages 6 months to 79 years with brain biopsy-proven herpes simplex encephalitis were randomized to receive acyclovir either acyclovir (10 mg/kg acyclovir buy now every 8 hours) or vidarabine (15 mg/kg/day) for 10 days (28 were treated with acyclovir and 34 with vidarabine). Caution should be acyclovir exercised in patients with history of kidney acyclovir disease, any allergy, during pregnancy and breast-feeding. Acyclovir Injection is a formulation for intravenous administration. Cerebrospinal fluid levels are approximately 50 of corresponding plasma acyclovir acyclovir asma protein binding is relatively low (9 to 33) and drug interactions involving binding site displacement are not anticipated. Medical Disclaimer Next Tips Add to My Med List More about acyclovir Consumer resources Professional resources Other brands: Zovirax, acyclovir Sitavig Related treatment guides. In doses of 10 mg/kg body weight every 8 hours provided renal function is not impaired (see Dosage in renal impairment).In obese patients dosed with intravenous aciclovir based on their actual body weight, higher plasma concentrations may acyclovir be obtained (see.2 Pharmacokinetic properties). 3 This drug is available at a higher level co-pay. Higher concentrations (e.g., 10 mg/mL) may produce phlebitis or inflammation at the injection site upon inadvertent extravasation. Treatment of Chickenpox: Children (2 years of age and older 20 mg/kg per dose orally 4 times daily (80 mg/kg/day) for 5 days. Renal impairment usually responds rapidly to rehydration of the patient and/or dosage acyclovir reduction or withdrawal of the drug. In adults, mean steady state peak plasma concentrations (Cssmax) following a one-hour infusion.5 acyclovir mg/kg, 5 mg/kg and 10 mg/kg were.7 micromolar (5.1 microgram/ml.6 micromolar (9.8 microgram/ml) and 92 micromolar (20.7 microgram/ml) respectively. Treatment for herpes encephalitis usually lasts 10 days. Side effects that affect the skin as well as allergic reactions have occurred. Dosage in infants and children: The dose of Zovirax.V. Adult Skin Problems Slideshow, quiz: Is Ringworm Contagious? These symptoms may be marked, particularly in older adults (see precautions). Varicella zoster infections or patients with herpes encephalitis should be given Zovirax.V. Herpes simplex infections in immunocompromised patients and severe initial genital herpes in the non-immunocompromised. Acyclovir should be used during pregnancy only if acyclovir the potential benefit justifies the potential risk to the fetus. Genital herpes refers to a sexually acyclovir transmitted disease sTD ) that any sexually active person can contract and transmit. Immune system disorders: Very rare: anaphylaxis. Immunocompromised patients: 10-15 mg/kg IV q8hr for 7-10 days. Carcinogenicity: Aciclovir acyclovir was not found acyclovir available in india to be carcinogenic in long-term studies in the rat and the mouse. Impaired kidney function Major, acyclovir 500 MG Injection should be used with caution in the patients with the pre-existing kidney injury. Practo acyclovir only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. Table acyclovir 5: Dosage Adjustments for Patients acyclovir with Renal Impairment Creatine Clearance (mL/min/1.73 m2) acyclovir dosage Percent of Recommended Dose Dosing Interval (hours) Hemodialysis: For patients who require dialysis, the mean plasma half-life of acyclovir during hemodialysis is approximately 5 hours. Has been inadvertently infused into extracellular tissues. Suitable dose adjustments or an alternate medicine should be considered based on the clinical condition. This has resulted in elevated BUN and serum creatinine, and subsequent renal failure. Neurological disorder Moderate, use of high-dose acyclovir intravenous Acyclovir 500 MG Injection may increase the risk of neurotoxicity, especially in the elderly population with a neurological disorder, kidney or liver injury. The contents of the vial should be dissolved in Sterile Water for Injection as follows: Contents of Vial - Amount of Diluent 500 mg 10 mL 1000 mg. The resulting solution online acyclovir acyclovir contains 50 mg acyclovir per mL (pH approximately 11). In doses of 250 mg per square metre of body surface area every 8 hours if renal function is not immunocompromised children with. The chemical name of acyclovir is sodium. In the reported cases, these reactions were generally acyclovir reversible on discontinuation of treatment (see section.8 Undesirable effects). Mayne Pharma (USA) Inc. Ninety-four (94) patients were evaluated (52 patients were treated with acyclovir and 42 with placebo). Approximately 1 of patients receiving intravenous acyclovir have manifested acyclovir encephalopathic changes characterized by either lethargy, obtundation, tremors, confusion, hallucinations, agitation, seizures, or coma. This is accomplished in three ways: 1) competitive inhibition of viral DNA polymerase, 2) incorporation into and termination of the growing viral DNA chain, and 3) inactivation of the viral DNA polymerase. Dosage AND administration caution rapid OR bolus intravenous injection must BE avoided (see warnings and precautions). Refrigeration of reconstituted solution may result in the formation of a precipitate which will redissolve at room temperature. Administration, the calculated dose should then be removed and added to any appropriate acyclovir intravenous solution at a volume selected for administration during each 1 hour infusion. Ivory RepublicEcuadorEgyptEl SalvadorEquatorial Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaPolynesia (French)Guam (USA)GuatemalaGuineaGuinea BissauGuyanaHaitiHondurasHong and Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina Islands (British)Virgin Islands (USA)Wallis and Futuna IslandsMartinique Caledonia (French)New IslandKorea-NorthNorthern Mariana New IslandPolandPortugalPuerto RicoQatarReunion HelenaSaint Kitts Nevis AnguillaSaint LuciaSaint Vincent acyclovir GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi IslandsSomaliaSouth AfricaKorea-SouthSouth. While most of the acyclovir-resistant mutants isolated thus far from such patients have been found to be TK-deficient mutants, other mutants involving the viral TK gene (TK partial and TK altered) and DNA polymerase have been isolated. Is indicated for the treatment of herpes encephalitis. Respiratory, thoracic and mediastinal disorders: Very rare: dyspnoea. See detailed T C here. Our Pharma Division deals only with the best, GMP certified generics and branded medication for the export market. This includes side effects that may affect the liver. These levels would potentially expose nursing infants to aciclovir dosages of up.3 mg/kg body weight/day. Initial Episodes of Herpes Genitalis In placebo-controlled trials, 58 patients with initial genital herpes were treated with intravenous acyclovir 5 mg/kg or placebo (27 patients treated with acyclovir and 31 treated with placebo) every 8 hours for 5 days. Herpes simplex infections inimmunocompromised patients. Store between 15 to 25 C (59 to 77 F). The corresponding trough levels (Cssmin) 7 hours later were.2 micromolar (0.5 microgram/ml.1 micromolar (0.7 microgram/ml) and.2 micromolar (2.3 microgram/ml) respectively. Dosage adjustments in infants and children: Creatinine Clearance Dosage 25 to 50 ml/min/1.73m2 The dose recommended above (250 or 500 mg/m2 body surface area or 20 mg/kg body weight) should be given every 12 hours. Dose adjustments or an alternate treatment is considered based on the clinical condition. Each 20 mL vial contains acyclovir sodium equivalent to 1000 mg of acyclovir. The recommended regimen for infants treated for known or suspected neonatal herpes is acyclovir 20 mg/kg body weight IV every 8 hours for 21 days for disseminated and CNS disease, or for 14 days for disease limited. Edition: close, please confirm that you would like to log out of Medscape. Genital herpes is an STD caused by two types of viruses: herpes simplex type 1 and herpes simplex type. Pediatrics (Under 12 years of age 20 mg/kg infused at a constant rate acyclovir over 1 hour, every 8 hours for 7 days. Thus one acyclovir 100 ml infusion bag may be used for any dose between 250 mg and 500 mg aciclovir (10 and 20 ml of reconstituted solution) but a second bag must be used for doses between 500 mg and 1000. You may report side effects to FDA at 1-800-FDA-1088 or at www. Concentrations achieved at these regimens are similar to those in adults receiving 5 mg/kg and 10 mg/kg every 8 hours, acyclovir respectively (Table 1). Varicella zoster infections: zoster IN immunocompromised patients : Adults and Adolescents (12 years of age and older 10 mg/kg infused at a constant rate over 1 hour, every 8 hours for 7 days. Acyclovir Injection is available in 20 mL and 40 mL vials, with each mL containing acyclovir sodium equivalent to 25 mg acyclovir. Adults and Children over 40 kg: 800 mg 4 times daily for 5 days. Nursing Mothers Acyclovir concentrations have been documented in breast milk in 2 women following oral administration of acyclovir and ranged from.6.1 times corresponding plasma levels. If you log out, you will be required to enter your username and password the next time you visit. All orders will be subject to courier charges and supplies are normally dispatched through acyclovir internationally accredited courier services. Date of revision of the text. CrCl 10-25 mL/min: Full recommended IV dose once acyclovir daily. Name of the medicinal product. Written Compiled by Anushta Chandrapalan Medically Reviewed by The Medindia Medical Review Team on Sep 26, 2013 Disclaimer : The Price of the drugs indicated above may not match the actual price at which they are sold. Systemic administration of aciclovir in internationally accepted standard tests did not produce embryotoxic or teratogenic effects in rabbits, rats or mice. Tell your doctor right away if you have any serious side effects, including: pain/swelling at the injection site, shaking, dizziness, drowsiness, unusual tiredness, fast/pounding heartbeat, easy bruising/bleeding, new signs of infection (e.g., fever, persistent sore throat dark urine, severe. In patients receiving haemodialysis the dose recommended above (250 or 500 mg/m2 body surface area or 20 mg/kg body weight) should be halved and administered every 24 hours and after dialysis.3 Contraindications Hypersensitivity to aciclovir or valaciclovir. Excipients with known effect: Sodium hydroxide For the full list of excipients, see section.1. Inform the doctor if you experience any symptoms such as sudden weight gain, changes in the frequency of the urination. To avoid this effect the drug should not be given as an intravenous bolus injection but by slow infusion over a one-hour ry rare: renal impairment, acute renal failure and renal equate hydration should be maintained. Marketing acyclovir authorisation number(s) PL 00003/0159. Usually lasts 5 days, but this may be adjusted according to the patient's condition and response to therapy. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. Aciclovir triphosphate interferes with the viral DNA polymerase and inhibits viral DNA replication with resultant chain termination following its incorporation into the viral DNA. Administration The calculated dose should then be removed and added to any appropriate intravenous solution at a volume selected for administration during each 1-hour infusion. To patients with impaired renal function. Dilution in any appropriate intravenous solution must be performed before infusion (see dosage acyclovir AND administration: Method of Preparation and Administration). Medindia currently has information on 3060 generic drugs and 110,006 brands that have their prices listed. Patients with Acute or Chronic Renal Impairment: Refer to dosage AND administration section for recommended doses, and adjust the dosing interval as indicated in the Table below. 6.6 Special precautions for disposal and other handling Reconstitution: Zovirax.V. Dosage in renal impairment below).Adequate hydration should be maintained. Other Precautions for Acyclovir (500 mg) Avoid contact with eyes and excess dosage. Obese Patients: Obese patients should be dosed at the recommended adult dose using Ideal Body Weight. Therapy should be initiated as early as possible following onset of signs and symptoms of herpes infections. Elevation of transaminases acyclovir occurred in 1 to 2 of patients. The inhibitory activity of acyclovir is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. Genitourinary : Kidney failure, elevated blood urea nitrogen levels, blood in urine and urinating less than acyclovir usual or not at all. Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important. The occurrence rate of birth defects approximates that found in the general population. Blood : Anemia, decrease in white blood cells and platelets. Prices can change depending on many factors, including GST. Add More Products Remove Product 2, note : We do not supply schedule-H (Example - narcotic drug or psychotropic drugs or anabolic steroids) and Anti- Abortion Drugs. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Adequate hydration should be maintained. Very rare: diarrhoea, abdominal pain. In patients receiving haemodialysis the dose recommended above (5 or 10 mg/kg body weight) should be halved and administered every 24 hours and after dialysis. Dosage adjustment for patients with renal impairment is based on creatinine clearance, in units of ml/min for adults and adolescents and in units of ml/min/1.73m2 for infants and children less than 13 years of age. Gallery of Skin Problems and Image Collection.
There were no important drug-induced alterations in acyclovir values for serum biochemical tests, acyclovir urinalyses and electrocardiographic tests done tablets at appropriate intervals during this tablets study. In some cases, they may not be available in all acyclovir strengths or forms as the acyclovir brand-name acyclovir drug. Acyclovir should tablets be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Chickenpox Acyclovir is indicated for the treatment of acyclovir chickenpox (varicella). Virology The quantitative relationship between the in vitro susceptibility of herpes simplex virus (HSV) and varicella-zoster viruses (VZV) to acyclovir and the clinical response to therapy has not been tablets established in man, and virus sensitivity testing has not been standardized. However, an acyclovir -resistant HSV infection in an immunosuppressed bone marrow transplant recipient tablets on extended acyclovir therapy was found to be due to a acyclovir clinical isolate which had a normal thymidine kinase but an altered DNA polymerase. It was demonstrated that acyclovir is not dose proportional over the dosing range acyclovir 200 to 800. Plasma fag/mL) Acyclovir Concentrations (Mean and.E.) Amniotic Fluid fag/mL) Fetal Homogenate g/mL (nmoles/g wet wt) 6.250.03.890.18.16 (0.690.13).5.250.05.036.37.21 (0.920.14) 25.390.12*.164.25.32 (1.400.19) *N5 Reproduction Fertility Acyclovir was. Avoid the sun if you can. Chronic herpetic infection in an immunocompromised patient: report of a case. Jama 1988; 260(15 2227-2230. Nervous: Aggressive behavior, agitation, ataxia, coma, confusion, decreased consciousness, delirium, dizziness, dysarthria, encephalopathy, hallucinations, paresthesia, psychosis, seizure, somnolence, tremors. These concentrations would potentially expose the nursing infant to a dose of acyclovir up.3 mg/kg/day. During the toxicosis induced by the larger doses of acyclovir, plasma levels of the drug were likely very high (as indicated by initial mean values.0 g/mL (106.6 M) for high-dose males and.4 g/mL (77.2 M) for high-dose. Ann Intern Med 1982; 96(3 265-269. The problem of drug-induced resistance in viruses, in Problems of Antiviral Therapy. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Viral resistance in clinical practice: summary of five years experience with acyclovir acyclovir. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. Ann Intern Med 1986; 104(6 786-790. Thus, there was no indication of enhanced metabolism of acyclovir as a result of chronic treatment. Dosage reduction may be required in geriatric patients with reduced renal function (see dosage AND administration ). rabbit (50 mg/kg/day,.c. Drug Resistance acyclovir Resistance of HSV and VZV to acyclovir can result from acyclovir qualitative and quantitative changes in the viral TK and/or DNA polymerase. All studies were performed in the presence and in the absence of exogenous mammalian metabolic activation. In a similar double-blind, placebo-controlled study, acyclovir (800 mg 5 times daily for 7 days) shortened the times to complete lesion scabbing, healing, and cessation of pain; reduced the duration of new lesion formation; and reduced the prevalence of localized zoster-associated neurologic. A combination of the thymidine kinase specificity, inhibition of DNA polymerase and premature termination of DNA synthesis results in inhibition of herpes virus replication. Collins P, Larder BA, Oliver NM, Kemp S, Smith IW, Darby. In 15 female rabbits treated intravenously with 50 mg/kg/day acyclovir on days 6 to 18 of gestation, there was no effect on either implantation efficiency or litter size. usa online casinos for android
Canadian generic acyclovir
When you order Acyclovir from m you have peace of mind acyclovir as we protect your privacy with generic a acyclovir secure ordering process. Australia 3 /4.5 generic gm.00, zovirax Dispersible Tablet, gSK. Doses should never be skipped; neither should you stop the treatment course prematurely. Other Side Effects : Less serious side acyclovir effects include: nausea, vomiting, diarrhea, loss of appetite, stomach pain, headache, feeling light headed, acyclovir or swelling in the hands or feet. You may report side effects to acyclovir FDA acyclovir at 1-800-FDA-1088). The side effects listed below usually do not necessarily require any acyclovir medical attention (please do report them to your physician if they are acyclovir recurrent or bothersome diarrhea fever acyclovir headaches nausea, vomiting upset stomach, generic other side effects are also possible. The confidential information provided by you, including credit card information, is generic never shared with other parties. Before taking Zovirax, tell your doctor if you are allergic to any drugs or if you have kidney disease. . We offer a low price guarantee (price match) when you order Acyclovir online canadian against any competing cipa certified online pharmacy website. Zovirax passes into breast milk and may harm a breast-feeding baby. . Zovirax will not prevent the spread of genital herpes. . Avoid touching the infected area and then touching your eyes. . Take it orally accompanied with a glass of water. Warnings : This medicine is not expected to harm an unborn baby. . This drug works best when the treatment is started early in the course of an infection. Genital herpes is a sexually transmitted disease. Place your order and buy Acyclovir today at m, a global leader of Canadian based online pharmacies and a trusted online Canadian pharmacy since 2002. Inform you doctor if you are pregnant or plan to become pregnant during treatment. Product Information : General Information : Precaution : Herpes infections are contagious. . The content on this page has been supplied to canadianpharmacyking by an independent third generic party canadian contracted to provide information for our website. Please note that not all products, canadian including any referenced in this page, are shipped by our affiliated Canadian Pharmacy.